180 Results for "

Dictamnus angustifolius G. Don ex Sweet

" in MedChemExpress (MCE) Product Catalog:
Products (180)

180 Results for "Dictamnus angustifolius G. Don ex Sweet" in MCE Product Catalog:

17
17 Publications Verification
Cat. No.: HY-108357
CAS No.: 157-03-9
Pureté:  99.98%
Synonyms: L-6-Diazo-5-oxonorleucine; Don
Domaines de recherche:  

Infection Cancer

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity .
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9
9 Cited Publications
Cat. No.: HY-122218
CAS No.: 1998725-11-3
Pureté:  ≥98.0%
Target:  

Glutaminase

Domaines de recherche:  

Neurological Disease

JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b + cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals .
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9
9 Cited Publications
Cat. No.: HY-N0298
CAS No.: 471-87-4
Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.
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4
4 Cited Publications
Cat. No.: HY-N0242
CAS No.: 28808-62-0
Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1 .
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4
4 Cited Publications
Cat. No.: HY-N8377
CAS No.: 205687-01-0
Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1 .
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3
3 Cited Publications
Cat. No.: HY-W030796A
CAS No.: 150436-68-3
Target:  

Taste Receptor

Domaines de recherche:  

Metabolic Disease

Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets .
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3
3 Cited Publications
Cat. No.: HY-W030796
CAS No.: 13794-15-5
Target:  

Taste Receptor

Domaines de recherche:  

Metabolic Disease

Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets .
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1
1 Cited Publications
Cat. No.: HY-N6887
CAS No.: 438045-89-7
Rebaudioside F is a steviol glycoside isolated from Stevia rebaudiana leaves. is a new natural sweet ingredient .
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1
1 Cited Publications
Cat. No.: HY-N2459
CAS No.: 134-01-0
Synonyms: YGM-6 chloride
Peonidin (YGM-6) chloride is an anthocyanin compound found in plants such as grapes and purple-fleshed sweet potatoes. Peonidin chloride alone exerts no stable inhibitory effect on LPS (HY-D1056)-mediated inflammatory gene expression. The acylated form of Peonidin chloride exhibits antimutagenic activity .
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1
1 Cited Publications
Cat. No.: HY-N6833
CAS No.: 1220616-44-3
Rebaudioside M, a glycoside of the ent-kaurene diterpenoid aglycone, is a non-calorie sweetener isolated from Stevia rebaudiana. Rebaudioside M has antidiabetics, antihypertension, anti-inflammatory, antioxidant, anticaries and anticancer benefits. Rebaudioside M is more than 350 times sweeter than sucrose. Rebaudioside M can be used in food and beverage .
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1
1 Cited Publications
Cat. No.: HY-139338
CAS No.: 13101-54-7
Pureté:  ≥99.0%
Erlose is a trisaccharide sucrose derivative and low-calorie sweetener synthesized from glucose and sucrose via an α-glucosidase-mediated transglycosylation reaction. Erlose is often used as a marker to identify whether honey is adulterated with artificial sucrose. Erlose has approximately half the sweetness of sucrose but a similar taste, and it effectively inhibits crystal formation and browning reactions during food heat treatment .
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1
1 Cited Publications
Cat. No.: HY-N2541
CAS No.: 122168-40-5
Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I is an antisweetness inhibitor via human sweet receptor type 1 receptor 2 (T1R2) and T1R3. Gymnemic acid I is a ribosomal protein biosynthesis inhibitor. Gymnemic acid I has antidiabetic effects. Gymnema acid I induces autophagy-protected MIN-6 cells from apoptosis under high glucose stress by inhibiting the phosphorylation activity of mTOR .
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Cat. No.: HY-N0466
CAS No.: 58543-16-1
Rebaudioside A is an orally effective steviol glycoside with high sweetness. Rebaudioside A acts as an inhibitor of α-glucosidase with an IC50 value of 35.01 μg/mL. Rebaudioside A increases the ATP/ADP ratio in β cells in a glucose-dependent manner, thereby inhibiting KATP channels, leading to membrane depolarization, calcium influx, and ultimately stimulating insulin secretion. Rebaudioside A activates the SREBP signaling pathway by inhibiting HMGCR, the rate-limiting enzyme in cholesterol synthesis, resulting in increased expression of LDLR on the cell surface, thus promoting the uptake of LDL-C in the blood. Rebaudioside A can be used for studies on blood glucose and lipid regulation as well as anti-obesity .
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Cat. No.: HY-N11678
CAS No.: 131180-21-7
Synonyms: Don-3-β-D-glucoside; Deoxynivalenol 3-glucoside
Target:  

Drug Metabolite

Deoxynivalenol-3-β-D-glucoside (DON-3-β-D-glucoside) is a plant metabolite of the Fusarium mycotoxin Deoxynivalenol (HY-N6684). Deoxynivalenol-3-β-D-glucoside exhibits lower toxicity than Deoxynivalenol in vitro and in vivo .
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Cat. No.: HY-N0467
CAS No.: 63550-99-2
Synonyms: Dulcoside B
Rebaudioside C (Dulcoside B) is an orally effective natural sweetener that cannot pass the blood-brain barrier and selectively binds to human sweet taste receptors (TAS1R2/TAS1R3). The sweetness of Rebaudioside C is about 20-30 times that of sucrose, and its sweetness activity depends on the C-16/C-17 double bond structure and specific aglycones. The glycoside structure in the Rebaudioside C molecule can bind to the sweet taste receptor, activate the taste signal transduction pathway, and produce sweetness perception .
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Cat. No.: HY-129847
CAS No.: 80863-62-3
Pureté:  99.79%
Domaines de recherche:  

Others

Alitame is a nonnutritive high-intensity sweetener, 2000 times sweeter than sucrose with no bitter or metallic aftertaste. Alitame is composed of L-aspartic acid, D-alanine, and a C-terminal amide moiety .
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Cat. No.: HY-119926
CAS No.: 15358-48-2
Synonyms: Hydroxylupanine
Target:  

Integrin

Domaines de recherche:  

Cardiovascular Disease Neurological Disease

13-Hydroxylupanine (Hydroxylupanine) is the typical alkaloid profile of sweet lupins.13-Hydroxylupanine blocks ganglionic transmission, decreases cardiac contractility and contracts uterine smooth muscle .
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Cat. No.: HY-139091
CAS No.: 1359963-68-0
Pureté:  99.85%
Target:  

Taste Receptor

Domaines de recherche:  

Others

FEMA 4774 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer .
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Cat. No.: HY-W032970
CAS No.: 534-73-6
Target:  

Others

Domaines de recherche:  

Others

Isomaltitol is a sugar alcohol sweet tastant. Isomaltitol affects adhesion between leukocytes and activated endothelium .
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Cat. No.: HY-N6942
CAS No.: 88901-41-1
Mogroside IV-A, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities .
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